![]() ![]() The FDA has granted orphan drug status to CoQ10 for the treatment of mitochondrial cytopathies.Īlthough the most common clinical use of CoQ10 is in heart disease, hypertension, and immunodepression, it is a powerful antioxidant. CoQ10 has not consistently improved athletic performance. CoQ10 prophylaxis has been associated with decreased serum markers of peroxidative damage and with myocardial preservation.4 Reported evidence to date does not currently justify its routine use in any of the cited conditions. Several open and placebo-controlled studies have demonstrated some benefit in patients having cardiovascular surgery, such as cardiac valve replacement, coronary artery bypass grafting, and repair of abdominal aortic aneurysms. Since no official standards have been established to date to regulate the production of dietary supplements in the United States, dosage ranges must be employed as guidelines only.ĬoQ10 is well documented as a potentially efficacious and adjunctive agent for the treatment of CHF and cardiomyopathy. CoQ10 is also involved in prevention of atherosclerosis, abnormal protein synthesis, and age-related degenerative diseases, and is a cell-membrane stabilizer.3 It also works as a powerful antioxidant due to its role in electron-transfer processes.ĬoQ10 is used as a supplement, and it should be noted that the dosing of dietary supplements is highly dependent on a variety of factors, such as quality of raw materials, manufacturing process, and packaging. In addition, CoQ10 may be of value in musculoskeletal disorders, periodontal disease, diabetes, and obesity. It is claimed that it is beneficial as a cardiotonic in a variety of cardiovascular diseases, including angina, congestive heart failure (CHF), and hypertension. The heart contains the largest amount of mitochondria (cell powerhouse) of any muscle in the body, so it is not surprising that CoQ10 has been proven effective for treatment of heart disease. ATP serves as the cell's major energy source and drives a number of biological processes, including muscle contraction and the production of protein.2 ![]() CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, and diabetes.1 It is also reported that some prescription drugs may lower CoQ10 levels.1ĬoQ10 occurs naturally in the energy-producing center of the cell known as the mitochondria and is involved in making an important molecule, known as adenosine triphosphate (ATP). Of the 10 forms of coenzyme Q found in nature, only CoQ10 is synthesized in humans. It is produced by the human body (endogenous) and is necessary for the basic functioning of all cells. Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like compound that is also known as ubiquinone. ![]()
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